FTO genotype is associated with phenotypic variability of body mass index

J Yang; RJF Loos; JE Powell; SE Medland; EK Speliotes; DI Chasman; LM Rose; G Thorleifsson; V Steinthorsdottir; R Mägi; L Waite; A Vernon Smith; LM Yerges-Armstrong; KL Monda; D Hadley; A Mahajan; G Li; K Kapur; V Vitart; JE Huffman; SR Wang; C Palmer; T Esko; K Fischer; J Hua Zhao; A Demirkan; A Isaacs; MF Feitosa; J Luan; NL Heard-Costa; C White; AU Jackson; M Preuss; A Ziegler; J Eriksson; Z Kutalik; F Frau; IM Nolte; JV Van Vliet-Ostaptchouk; JJ Hottenga; KB Jacobs; N Verweij; A Goel; C Medina-Gomez; K Estrada; JL Bragg-Gresham; S Sanna; C Sidore; J Tyrer; A Teumer; I Prokopenko; M Mangino; CM Lindgren; TL Assimes; AR Shuldiner; J Hui; JP Beilby; WL McArdle; P Hall; T Haritunians; L Zgaga; I Kolcic; O Polasek; T Zemunik; BA Oostra; M Juhani Junttila; H Grönberg; S Schreiber; A Peters; AA Hicks; J Stephens; NS Foad; J Laitinen; A Pouta; M Kaakinen; G Willemsen; JM Vink; SH Wild; G Navis; FW Asselbergs; G Homuth; U John; C Iribarren; T Harris; L Launer; V Gudnason; JR O'Connell; E Boerwinkle; G Cadby; LJ Palmer; AL James; AW Musk; E Ingelsson; BM Psaty; JS Beckmann; G Waeber; P Vollenweider; C Hayward; AF Wright; I Rudan

Journal article

FTO genotype is associated with phenotypic variability of body mass index

J Yang, RJF Loos, JE Powell, SE Medland, EK Speliotes, DI Chasman, LM Rose, G Thorleifsson, V Steinthorsdottir, R Mägi, L Waite, A Vernon Smith, LM Yerges-Armstrong, KL Monda, D Hadley, A Mahajan, G Li, K Kapur, V Vitart, JE Huffman Show all

Nature | Published : 2012

DOI: 10.1038/nature11401

Abstract

There is evidence across several species for genetic control of phenotypic variation of complex traits, such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important in evolutionary biology, agricultural selection programmes and human medicine, yet for complex traits, no individual genetic variants associated with variance, as opposed to the mean, have been identified. Here we perform a meta-analysis of genome-wide association studies of phenotypic variation using ∼170,000 samples on height and body mass index (BMI) in human populations. We report evidence that the single nucleotide polymorphism (SNP) rs7202116 at the FTO gene locus,..

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University of Melbourne Researchers

Mike Goddard Author

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Grants

Awarded by European Commission

Funding Acknowledgements

We acknowledge funding from the Australian National Health and Medical Research Council (NHMRC grants 241944, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 496688, 552485, 613672, 613601 and 1011506), the US National Institutes of Health (grants AA07535, AA10248, AA014041, AA13320, AA13321, AA13326, DA12854 and GM057091) and the Australian Research Council (ARC grant DP1093502). A detailed list of acknowledgements by study is provided in the Supplementary Information. We apologize to authors whose work we could not cite owing to space restrictions.